The Football Association has rejected Manchester City's appeal against Vincent Kompany's red card in the 3-2 FA Cup defeat by Manchester United.
The defender, 25, will serve a four-match ban immediately for his two-footed tackle on Nani.
Kompany will miss the Carling Cup semi-final first leg against Liverpool on Wednesday and the return on 25 January.
He will also be absent from the league trip to Wigan on Monday and the home game against Tottenham on 22 January.
An FA statement said: "The suspension consists of a statutory three-match suspension for serious foul play plus one additional game given this is Kompany's second dismissal of the season."
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